Target bp prior to obliteration of aneurysm

Therefore, POSTN has been paid attention to as a biomarker or a therapeutic target of inflammatory diseases. POSTN is closely related to inflammation and modulates immune and nonimmune cells as a matricellular protein. Periostin (POSTN) is a 90-kDa extracellular matrix protein belonging to the fasciclin family, which was originally reported as osteoblast-specific factor 2. The mechanisms of post-SAH brain injury are multifactorial, but neuroinflammation is considered as an important cause. Patients who survive an early stage of aneurysmal SAH and have their aneurysms obliterated are still at risk of delayed cerebral ischemia (DCI) that often results in severe disabilities or death. These findings suggest POSTN as a new therapeutic molecular target against post-SAH DCI.ДЄneurysmal subarachnoid hemorrhage (SAH) is a life-threatening disease even in these years. This study shows for the first time that CSF drainage may reduce plasma POSTN levels, and that POSTN levels may increase prior to the development of DCI with and without vasospasm irrespective of systemic inflammatory reactions in clinical settings. POSTN levels over the cutoff value were associated with higher incidence of DCI, but not angiographic vasospasm. Multivariate analyses using variables obtained by day 3 revealed that POSTN level was an independent predictor of DCI. To predict DCI development, receiver-operating characteristic curves indicated that the most reasonable cutoff POSTN levels were obtained at days 1вЂ“3 in patients without CSF drainage (80.5В ng/ml specificity, 77.6% sensitivity, 85.7%). There was no correlation between POSTN levels and other treatments or CRP levels. Cerebrospinal fluid (CSF) drainage was associated with reduced POSTN levels, but did not influence CRP levels. POSTN levels peaked at days 4вЂ“6 before DCI development. DCI developed in 16 patients associated with higher incidence of angiographic vasospasm, cerebral infarction, and 90-day worse outcomes.

The aim of the present study was to investigate the relationship between plasma POSTN levels and various clinical factors including serum levels of C-reactive protein (CRP), an inflammatory marker, in 109 consecutive SAH patients whose POSTN levels were measured at days 1вЂ“12 after aneurysmal obliteration. Matricellular protein periostin (POSTN) has been found to be upregulated and linked with early brain injury after experimental SAH.

Delayed cerebral ischemia (DCI) is a serious complication of aneurysmal subarachnoid hemorrhage (SAH).

Target bp prior to obliteration of aneurysm